Document Details

Document Type : Article In Journal 
Document Title :
Global genetic variation of select opiate metabolism genes in self-reported healthy individuals
Global genetic variation of select opiate metabolism genes in self-reported healthy individuals
 
Document Language : English 
Abstract : CYP2D6 is a key pharmacogene encoding an enzyme impacting poor, intermediate, extensive and ultrarapid phase I metabolism of many marketed drugs. The pharmacogenetics of opiate drug metabolism is particularly interesting due to the relatively high incidence of addiction and overdose. Recently, trans-acting opiate metabolism and analgesic response enzymes (UGT2B7, ABCB1, OPRM1 and COMT) have been incorporated into pharmacogenetic studies to generate more comprehensive metabolic profiles of patients. With use of massively parallel sequencing, it is possible to identify additional polymorphisms that fine tune, or redefine, previous pharmacogenetic findings, which typically rely on targeted approaches. The 1000 Genomes Project data were analyzed to describe population genetic variation and statistics for these five genes in self-reported healthy individuals in five global super- and 26 sub-populations. Findings on the variation of these genes in various populations expand baseline understanding of pharmacogenetically relevant polymorphisms for future studies of affected cohorts. 
ISSN : 1470-269X 
Journal Name : The Pharmacogenomics Journal 
Volume : 18 
Issue Number : 1 
Publishing Year : 1438 AH
2017 AD 
Article Type : Article 
Added Date : Wednesday, June 26, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
F R WendtWendt, F RInvestigatorDoctorateFrank.Wendt@my.unthsc.edu
G PathakPathak, G ResearcherDoctorate 
A SajantilaSajantila, A ResearcherDoctorate 
R ChakrabortyChakraborty, R ResearcherDoctorate 
B BudowleBudowle, B ResearcherDoctorate 

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