Document Details

Document Type : Article In Journal 
Document Title :
Fast STR allele identification with STRait Razor 3.0
Fast STR allele identification with STRait Razor 3.0
 
Document Language : English 
Abstract : The short tandem repeat allele identification tool (STRait Razor), a program used to characterize the haplotypes of short tandem repeats (STRs) in massively parallel sequencing (MPS) data, was redesigned. STRait Razor v3.0 performs ∼660× faster allele identification than its previous version (v2s), a speedup that is largely due to a novel indexing strategy used to perform "fuzzy" (approximate) string matching of anchor sequences. Written in a portable compiled language, C++, STRait Razor v3.0 functions on all major operating systems including Microsoft Windows, and it has cross-platform multithreading support. In silico estimates of precision and accuracy of STRait Razor v3.0 were 100% in this evaluation and results were highly concordant with those of Strait Razor v2s. STRait Razor v3.0 adds several key features that simplify the haplotype reporting process, including simple filters to remove low frequency haplotypes as well as merging haplotypes within a locus encoded on opposite strands of the DNA molecule. 
ISSN : 1872-4973 
Journal Name : Forensic Science International: Genetics 
Volume : 30 
Issue Number : 1 
Publishing Year : 1438 AH
2017 AD 
Article Type : Article 
Added Date : Wednesday, June 26, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
August E. WoernerWoerner, August E.InvestigatorDoctorateAugust.Woerner@unthsc.edu
Jonathan L. KingKing, Jonathan L.ResearcherDoctorate 
Bruce BudowleBudowle, Bruce ResearcherDoctorate 

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